FBXO45

Across TCGA cell cohorts, FBXO45 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,519 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible FBXO45-associated GO terms across cancer lineages are Maintenance of centrosome location, Interstrand cross-link repair, and DNA strand elongation. Each is linked with FBXO45 in more than 16 cancer types. Because this analysis shows association rather than direction, both FBXO45-to-partner and partner-to-FBXO45 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Maintenance of centrosome location grouped by FBXO45-low versus FBXO45-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (FBXO45→partner) and Y-score (partner→FBXO45) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Maintenance of centrosome location →	+0.206	+1.255	<.001	<.001	3	17
PANCREAS	Interstrand cross-link repair →	+0.088	+0.827	<.001	<.001	3	15
UPPER_AERODIGESTIVE_TRACT	DNA strand elongation →	+0.141	+0.907	.003	<.001	3	14
UPPER_AERODIGESTIVE_TRACT	DNA-templated DNA replication →	+0.119	+1.014	<.001	<.001	3	14
PANCREAS	Regulation of cell cycle checkpoint →	+0.093	+0.893	<.001	.001	3	13
SOFT_TISSUE	Protein localization to condensed chromosome →	+0.128	+0.629	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,519 associations by consensus.

Maintenance of centrosome location by FBXO45 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →