FBXO44

Across TCGA patient cohorts, FBXO44 mutation is significantly associated with the RNA expression of many other genes, with 162 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FBXO44-associated genes across cancer lineages are RNU5E-9P, SNORD116-10, and RNU6-484P. Each is linked with FBXO44 in more than 2 cancer types. Because this analysis shows association rather than direction, both FBXO44-to-partner and partner-to-FBXO44 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU5E-9P grouped by FBXO44-low versus FBXO44-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBXO44→partner) and Y-score (partner→FBXO44) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RNU5E-9P →	+0.449	+6.038	<.001	<.001	3	3
SKCM	SNORD116-10 →	+0.245	+4.624	<.001	.005	3	2
SKCM	RNU6-484P →	+0.553	+3.885	<.001	.004	3	2
SKCM	MIR670 →	+0.282	+4.624	<.001	.005	3	2
SKCM	GSTA11P →	+0.039	+5.485	<.001	.001	3	2
UCEC	PPP3R2 →	+0.086	+2.863	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 162 associations by consensus.

RNU5E-9P by FBXO44 expression — HNSC

Explore this box plot interactively →