FBXO42

Across TCGA patient cohorts, FBXO42 mutation is significantly associated with the RNA expression of many other genes, with 1,928 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FBXO42-associated genes across cancer lineages are MIR3661, HBAP1, and MIR3922. Each is linked with FBXO42 in more than 2 cancer types. Because this analysis shows association rather than direction, both FBXO42-to-partner and partner-to-FBXO42 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR3661 grouped by FBXO42-low versus FBXO42-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBXO42→partner) and Y-score (partner→FBXO42) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	MIR3661 →	+1.366	+3.829	<.001	.005	3	3
LUAD	HBAP1 →	+0.469	+4.631	<.001	<.001	3	2
LGG	MIR3922 →	+0.424	+5.602	<.001	.004	3	2
LIHC	ZNF679 →	+0.451	+3.903	.008	.007	3	2
LUSC	RNA5SP104 →	+0.295	+5.733	<.001	.001	3	2
UCEC	WDR59 →	+0.384	+2.502	.002	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,928 associations by consensus.

MIR3661 by FBXO42 expression — COAD

Explore this box plot interactively →