FBXO42

Across TCGA patient cohorts, FBXO42 mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FBXO42-associated genes across cancer lineages are EGFR_pY1068, FoxM1, and Gab2. Each is linked with FBXO42 in more than 1 cancer types. Because this analysis shows association rather than direction, both FBXO42-to-partner and partner-to-FBXO42 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by FBXO42-low versus FBXO42-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBXO42→partner) and Y-score (partner→FBXO42) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.299	-3.459	.006	.005	3	1
UCEC	FoxM1 →	+0.247	+2.115	.029	.019	3	1
UCEC	Gab2 →	+0.367	+2.115	.018	.019	3	1
UCEC	JNK2 →	+0.300	+3.179	<.001	.010	3	1
UCEC	MEK1 →	+0.444	+3.459	.005	.005	3	1
UCEC	mTOR_pS2448 →	-0.183	-2.115	.005	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

EGFR_pY1068 by FBXO42 expression — UCEC

Explore this box plot interactively →