FBXO42

Across TCGA cell cohorts, FBXO42 mutation is significantly associated with the RNA expression of many other genes, with 96 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FBXO42-associated genes across cancer lineages are SMYD1, OR10H2, and TRIM77. Each is linked with FBXO42 in more than 1 cancer types. Because this analysis shows association rather than direction, both FBXO42-to-partner and partner-to-FBXO42 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SMYD1 grouped by FBXO42-low versus FBXO42-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBXO42→partner) and Y-score (partner→FBXO42) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	SMYD1 →	+0.012	+4.357	<.001	.006	3	1
UPPER_AERODIGESTIVE_TRACT	OR10H2 →	+0.097	+4.209	<.001	.006	3	1
UPPER_AERODIGESTIVE_TRACT	TRIM77 →	+0.022	+4.357	<.001	.006	3	1
LUNG_NSCLC_LUAD	TGM7 →	+0.006	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	SPATA31D1 →	+0.006	+5.228	<.001	.005	3	1
LARGE_INTESTINE	TIMM9 →	+0.596	+3.212	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 96 associations by consensus.

SMYD1 by FBXO42 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →