FBXO40

Across TCGA patient cohorts, FBXO40 mutation is significantly associated with the RNA expression of many other genes, with 3,581 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FBXO40-associated genes across cancer lineages are LRRC59, ITGB1BP1, and SLC35B1. Each is linked with FBXO40 in more than 3 cancer types. Because this analysis shows association rather than direction, both FBXO40-to-partner and partner-to-FBXO40 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LRRC59 grouped by FBXO40-low versus FBXO40-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBXO40→partner) and Y-score (partner→FBXO40) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	LRRC59 →	+0.510	+3.043	<.001	<.001	3	4
UCEC	ITGB1BP1 →	+0.330	+2.917	.002	<.001	3	4
UCEC	SLC35B1 →	+0.406	+1.895	<.001	.001	3	4
UCEC	CDCA5 →	+0.896	+2.212	<.001	<.001	3	4
UCEC	UHRF1 →	+1.011	+2.212	<.001	<.001	3	3
UCEC	CCT5 →	+0.529	+2.376	.002	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,581 associations by consensus.

LRRC59 by FBXO40 expression — UCEC

Explore this box plot interactively →