FBXO40

Across TCGA patient cohorts, FBXO40 mutation is significantly associated with the total protein of many other genes, with 52 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FBXO40-associated genes across cancer lineages are 4E-BP1, FoxM1, and PDCD4. Each is linked with FBXO40 in more than 4 cancer types. Because this analysis shows association rather than direction, both FBXO40-to-partner and partner-to-FBXO40 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by FBXO40-low versus FBXO40-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBXO40→partner) and Y-score (partner→FBXO40) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.354	+2.614	<.001	.005	2	5
UCEC	FoxM1 →	+0.338	+3.321	<.001	<.001	3	3
UCEC	PDCD4 →	-0.548	-1.765	.001	.014	3	2
COAD	TSC1 →	-0.448	-2.459	<.001	.018	3	2
UCEC	EGFR_pY1068 →	-0.260	-2.584	.005	.010	3	2
UCEC	FOXO3a_pS318_S321 →	-0.102	-1.575	.029	.034	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 52 associations by consensus.

4E-BP1 by FBXO40 expression — UCEC

Explore this box plot interactively →