FBXO40

Across TCGA cell cohorts, FBXO40 mutation is significantly associated with the RNA expression of many other genes, with 41 significant associations in total. STOMACH shows the largest number of these associations.

The most reproducible FBXO40-associated genes across cancer lineages are OR56B1, SPHKAP, and GHRHR. Each is linked with FBXO40 in more than 1 cancer types. Because this analysis shows association rather than direction, both FBXO40-to-partner and partner-to-FBXO40 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR56B1 grouped by FBXO40-low versus FBXO40-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBXO40→partner) and Y-score (partner→FBXO40) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	OR56B1 →	+0.027	+3.103	.007	.004	3	2
STOMACH	SPHKAP →	+0.008	+3.432	.005	.008	3	2
BLOOD_Leukemia	GHRHR →	+0.322	+3.705	<.001	.007	3	1
BLOOD_Leukemia	IL1RL2 →	+0.039	+3.847	.003	.007	3	1
BLOOD_Leukemia	ADRA1A →	+0.180	+3.705	<.001	.007	3	1
BLOOD_Leukemia	BTBD16 →	+0.107	+3.959	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

OR56B1 by FBXO40 expression — SKIN

Explore this box plot interactively →