FBXO40

Across TCGA cell cohorts, FBXO40 mutation is significantly associated with the mutation status of many other genes, with 3,640 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FBXO40-associated genes across cancer lineages are ATP2A1, KCNK3, and PTPRM. Each is linked with FBXO40 in more than 3 cancer types. Because this analysis shows association rather than direction, both FBXO40-to-partner and partner-to-FBXO40 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATP2A1 grouped by FBXO40-low versus FBXO40-high in STOMACH.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBXO40→partner) and Y-score (partner→FBXO40) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	ATP2A1 →	+3.584	+3.584	.006	.006	1	4
LUNG_NSCLC_LUAD	KCNK3 →	+5.000	+4.187	.008	.008	1	4
LARGE_INTESTINE	PTPRM →	+1.632	+2.502	.005	.005	1	4
LARGE_INTESTINE	PIGN →	+2.632	+2.906	<.001	<.001	1	4
LARGE_INTESTINE	PTPN4 →	+2.369	+2.471	.005	.005	1	3
LARGE_INTESTINE	GANAB →	+3.632	+2.874	.002	.002	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,640 associations by consensus.

ATP2A1 by FBXO40 expression — STOMACH

Explore this box plot interactively →