FBXO4

Across TCGA pan-cancer cohorts, FBXO4 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated FBXO4 data layer compared with 22 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher FBXO4 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated FBXO4 expression acts as an unfavorable survival marker, although some lineages such as PDAC and UCEC show a favorable association.

HNSC, PDAC, and LSCC are the cancer types where FBXO4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.891	0.989	<.001	40	view →
PDAC	DFS	Quartile	All	0.873	0.705	.006	23	view →
LSCC	DFS	Tertile	II,III,IV	0.471	0.848	.006	20	view →
CCRCC	DFS	Quartile	II,III,IV	0.306	0.851	.002	14	view →
UCEC	DFS	Tertile	All	1.000	0.833	.009	6	view →
LUAD	OS	Quartile	All	0.659	1.000	.019	4	view →
GBM	OS	Tertile	All	0.624	0.463	.038	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

FBXO4–HNSC (DFS)

Open the HNSC breakdown →