FBXO39

Across TCGA patient cohorts, FBXO39 mutation is significantly associated with the RNA expression of many other genes, with 768 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FBXO39-associated genes across cancer lineages are ZWILCH, MAP3K9, and RPL7AP69. Each is linked with FBXO39 in more than 1 cancer types. Because this analysis shows association rather than direction, both FBXO39-to-partner and partner-to-FBXO39 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZWILCH grouped by FBXO39-low versus FBXO39-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBXO39→partner) and Y-score (partner→FBXO39) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ZWILCH →	+0.723	+3.470	.001	.003	3	2
UCEC	MAP3K9 →	+0.705	+3.470	<.001	.003	3	2
BLCA	RPL7AP69 →	+0.060	+4.973	<.001	.009	3	2
UCEC	RNA5SP412 →	+1.206	+2.967	<.001	<.001	3	2
BLCA	RNU6-650P →	+0.607	+5.038	<.001	.009	3	2
HNSC	OR4D11 →	+0.065	+4.548	.003	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 768 associations by consensus.

ZWILCH by FBXO39 expression — UCEC

Explore this box plot interactively →