FBXO39

Across TCGA patient cohorts, FBXO39 mutation is significantly associated with the immune_cell of many other genes, with 9 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible FBXO39-associated genes across cancer lineages are MEP, Th2 cells, and GMP. Each is linked with FBXO39 in more than 1 cancer types. Because this analysis shows association rather than direction, both FBXO39-to-partner and partner-to-FBXO39 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEP grouped by FBXO39-low versus FBXO39-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBXO39→partner) and Y-score (partner→FBXO39) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	MEP →	+0.020	+1.893	.044	.030	3	2
SKCM	Th2 cells →	+0.131	+1.421	.039	.030	3	2
COAD	GMP →	+0.149	+3.562	<.001	.015	3	2
HNSC	CD8+ T-cells →	+0.033	+4.600	<.001	.001	3	2
SKCM	lymphatic Endothelial cells →	-0.016	-2.150	.040	.032	3	1
SKCM	mv Endothelial cells →	-0.024	-2.400	.013	.020	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

MEP by FBXO39 expression — SKCM

Explore this box plot interactively →