FBXO39

Across TCGA cell cohorts, FBXO39 mutation is significantly associated with the mutation status of many other genes, with 1,254 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FBXO39-associated genes across cancer lineages are FAP, ZBTB40, and OR10S1. Each is linked with FBXO39 in more than 2 cancer types. Because this analysis shows association rather than direction, both FBXO39-to-partner and partner-to-FBXO39 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FAP grouped by FBXO39-low versus FBXO39-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBXO39→partner) and Y-score (partner→FBXO39) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	FAP →	+2.630	+3.047	.005	.005	1	3
LUNG_SCLC	ZBTB40 →	+5.502	+5.502	.003	.003	1	3
BLOOD_Leukemia	OR10S1 →	+4.321	+5.285	.005	.005	1	3
LUNG_SCLC	PEX6 →	+5.502	+5.502	.003	.003	1	3
LARGE_INTESTINE	FGR →	+3.799	+3.329	.005	.005	1	2
LUNG_SCLC	ZNF471 →	+5.502	+5.502	.003	.003	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,254 associations by consensus.

FAP by FBXO39 expression — LARGE_INTESTINE

Explore this box plot interactively →