FBXO34

Across TCGA patient cohorts, FBXO34 mutation is significantly associated with the RNA expression of many other genes, with 3,620 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FBXO34-associated genes across cancer lineages are COQ3, EIF3M, and LEO1. Each is linked with FBXO34 in more than 3 cancer types. Because this analysis shows association rather than direction, both FBXO34-to-partner and partner-to-FBXO34 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, COQ3 grouped by FBXO34-low versus FBXO34-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBXO34→partner) and Y-score (partner→FBXO34) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	COQ3 →	+0.479	+2.263	.001	.005	3	4
UCEC	EIF3M →	+0.423	+4.063	.004	<.001	3	3
UCEC	LEO1 →	+0.464	+3.939	.001	<.001	3	3
UCEC	PEX3 →	+0.433	+2.628	.008	.005	3	3
UCEC	SNRNP40 →	+0.611	+3.807	<.001	<.001	3	3
UCEC	GEMIN2 →	+0.453	+2.332	.003	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,620 associations by consensus.

COQ3 by FBXO34 expression — UCEC

Explore this box plot interactively →