FBXO34

Across TCGA patient cohorts, FBXO34 mutation is significantly associated with the total protein of many other genes, with 47 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FBXO34-associated genes across cancer lineages are Caspase-7-cleavedD198, A-Raf_pS299, and FoxM1. Each is linked with FBXO34 in more than 2 cancer types. Because this analysis shows association rather than direction, both FBXO34-to-partner and partner-to-FBXO34 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by FBXO34-low versus FBXO34-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBXO34→partner) and Y-score (partner→FBXO34) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.683	+2.242	.002	.005	3	3
UCEC	A-Raf_pS299 →	-0.146	-2.700	.001	.006	3	2
UCEC	FoxM1 →	+0.219	+1.415	.024	.046	3	2
UCEC	Rab11 →	-0.128	-2.459	.019	.018	3	2
LUSC	Src_pY416 →	-0.396	-2.990	.041	.036	3	1
UCEC	14-3-3_beta →	-0.118	-2.673	.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 47 associations by consensus.

Caspase-7-cleavedD198 by FBXO34 expression — UCEC

Explore this box plot interactively →