FBXO34

Across TCGA cell cohorts, FBXO34 mutation is significantly associated with the RNA expression of many other genes, with 162 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FBXO34-associated genes across cancer lineages are SERPINA11, CEP76, and LIPG. Each is linked with FBXO34 in more than 1 cancer types. Because this analysis shows association rather than direction, both FBXO34-to-partner and partner-to-FBXO34 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SERPINA11 grouped by FBXO34-low versus FBXO34-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBXO34→partner) and Y-score (partner→FBXO34) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SERPINA11 →	+0.042	+2.459	<.001	.002	3	2
LARGE_INTESTINE	CEP76 →	+0.729	+3.364	.001	.002	3	1
LARGE_INTESTINE	LIPG →	+1.850	+3.169	<.001	.009	3	1
LARGE_INTESTINE	TBC1D12 →	+0.937	+3.364	<.001	.002	3	1
LARGE_INTESTINE	NCOA7 →	+1.341	+3.451	<.001	.002	3	1
LARGE_INTESTINE	FBXO6 →	+1.318	+3.364	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 162 associations by consensus.

SERPINA11 by FBXO34 expression — LARGE_INTESTINE

Explore this box plot interactively →