FBXO31

Across TCGA patient cohorts, FBXO31 mutation is significantly associated with the RNA expression of many other genes, with 2,490 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FBXO31-associated genes across cancer lineages are CYCSP22, VPS4B, and GCH1. Each is linked with FBXO31 in more than 2 cancer types. Because this analysis shows association rather than direction, both FBXO31-to-partner and partner-to-FBXO31 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CYCSP22 grouped by FBXO31-low versus FBXO31-high in READ.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBXO31→partner) and Y-score (partner→FBXO31) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
READ	CYCSP22 →	+0.206	+5.421	<.001	.005	3	3
UCEC	VPS4B →	+0.453	+2.238	.004	.006	3	3
UCEC	GCH1 →	+0.601	+2.295	<.001	<.001	3	3
UCEC	NARS1 →	+0.437	+2.263	.001	<.001	3	3
UCEC	TMED7 →	+0.509	+3.584	.008	.002	3	3
UCEC	KNL1 →	+0.654	+3.042	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,490 associations by consensus.

CYCSP22 by FBXO31 expression — READ

Explore this box plot interactively →