FBXO31

Across TCGA patient cohorts, FBXO31 mutation is significantly associated with the total protein of many other genes, with 52 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FBXO31-associated genes across cancer lineages are eIF4E, GAPDH, and 4E-BP1. Each is linked with FBXO31 in more than 2 cancer types. Because this analysis shows association rather than direction, both FBXO31-to-partner and partner-to-FBXO31 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by FBXO31-low versus FBXO31-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBXO31→partner) and Y-score (partner→FBXO31) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.236	+2.087	.003	.005	2	3
UCEC	GAPDH →	+0.521	+2.700	.011	.006	3	2
UCEC	4E-BP1 →	+0.401	+2.700	<.001	.005	3	2
UCEC	eEF2 →	+0.309	+1.678	.024	.023	3	2
UCEC	EGFR_pY1068 →	-0.210	-1.678	.029	.023	3	2
UCEC	GATA6 →	-0.142	-2.080	.016	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 52 associations by consensus.

eIF4E by FBXO31 expression — UCEC

Explore this box plot interactively →