FBXO30

Across TCGA patient cohorts, FBXO30 mutation is significantly associated with the RNA expression of many other genes, with 5,228 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FBXO30-associated genes across cancer lineages are LIN7C, APIP, and FAM177A1. Each is linked with FBXO30 in more than 1 cancer types. Because this analysis shows association rather than direction, both FBXO30-to-partner and partner-to-FBXO30 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LIN7C grouped by FBXO30-low versus FBXO30-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBXO30→partner) and Y-score (partner→FBXO30) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	LIN7C →	+0.557	+3.213	<.001	<.001	3	2
UCEC	APIP →	+0.435	+3.818	.001	<.001	3	2
UCEC	FAM177A1 →	+0.302	+2.732	.003	.002	3	2
UCEC	SCLT1 →	+0.338	+2.447	.003	.001	3	2
UCEC	VTI1A →	+0.385	+2.343	<.001	<.001	3	2
UCEC	C18orf25 →	+0.422	+2.518	.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,228 associations by consensus.

LIN7C by FBXO30 expression — UCEC

Explore this box plot interactively →