FBXO30

Across TCGA patient cohorts, FBXO30 mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FBXO30-associated genes across cancer lineages are PDCD4, Chk2_pT68, and C-Raf. Each is linked with FBXO30 in more than 1 cancer types. Because this analysis shows association rather than direction, both FBXO30-to-partner and partner-to-FBXO30 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDCD4 grouped by FBXO30-low versus FBXO30-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBXO30→partner) and Y-score (partner→FBXO30) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PDCD4 →	-0.639	-2.000	<.001	.003	3	2
UCEC	Chk2_pT68 →	-0.146	-3.295	.026	.009	3	2
UCEC	C-Raf →	+0.223	+2.874	<.001	<.001	3	2
UCEC	53BP1 →	+0.277	+2.000	.021	.029	3	2
UCEC	14-3-3_beta →	-0.096	-2.088	.006	.016	3	1
UCEC	EGFR_pY1068 →	-0.250	-2.000	.004	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

PDCD4 by FBXO30 expression — UCEC

Explore this box plot interactively →