FBXO28

Across TCGA pan-cancer cohorts, FBXO28 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated FBXO28 data layer compared with 24 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher FBXO28 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated FBXO28 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

HNSC, UCEC, and PDAC are the cancer types where FBXO28 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.484	0.985	.014	12	view →
UCEC	OS	Median	II,III,IV	1.000	0.620	.011	4	view →
PDAC	DFS	Median	All	0.302	0.569	.040	2	view →
CCRCC	OS	Tertile	II,III,IV	0.461	0.799	.036	1	view →
LSCC	DFS	Median	III,IV	0.882	1.000	.039	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

FBXO28–HNSC (DFS)

Open the HNSC breakdown →