FBXO28

Across TCGA pan-cancer cohorts, FBXO28 mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of FBXO28’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where FBXO28 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types FBXO28 is over-expressed in tumor.

LUAD, LSCC, and COAD are the cancer types where FBXO28 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FBXO28 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Female	All	+0.208	<.001	6	view →
LSCC	All	All	+0.104	<.001	4	view →
COAD	All	III,IV	+0.622	.010	2	view →
HNSC	All	III,IV	+0.211	.034	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

FBXO28–LUAD

Open the LUAD breakdown →