FBXO28

Across TCGA patient cohorts, FBXO28 mutation is significantly associated with the RNA expression of many other genes, with 1,284 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FBXO28-associated genes across cancer lineages are SEPTIN14P19, CDRT15P2, and RHOXF2B. Each is linked with FBXO28 in more than 2 cancer types. Because this analysis shows association rather than direction, both FBXO28-to-partner and partner-to-FBXO28 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SEPTIN14P19 grouped by FBXO28-low versus FBXO28-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBXO28→partner) and Y-score (partner→FBXO28) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	SEPTIN14P19 →	+0.078	+5.337	<.001	.006	3	3
CESC	CDRT15P2 →	+0.199	+6.342	<.001	.001	3	2
BLCA	RHOXF2B →	+0.706	+3.840	.002	.006	3	2
BLCA	TRGJP2 →	+0.759	+4.266	<.001	.003	3	2
UCEC	FAM243A →	+0.013	+4.744	<.001	.001	3	2
UCEC	RNU2-47P →	+0.066	+3.738	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,284 associations by consensus.

SEPTIN14P19 by FBXO28 expression — LUSC

Explore this box plot interactively →