FBXO28

Across TCGA patient cohorts, FBXO28 mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FBXO28-associated genes across cancer lineages are ERK2, p70-S6K_pT389, and PCNA. Each is linked with FBXO28 in more than 1 cancer types. Because this analysis shows association rather than direction, both FBXO28-to-partner and partner-to-FBXO28 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by FBXO28-low versus FBXO28-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBXO28→partner) and Y-score (partner→FBXO28) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.191	+1.584	.011	.036	3	2
UCEC	p70-S6K_pT389 →	-0.195	-2.321	.009	.033	3	2
UCEC	PCNA →	+0.262	+2.502	.001	.002	3	2
UCEC	Caspase-7-cleavedD198 →	+0.848	+2.000	<.001	.010	3	2
UCEC	14-3-3_beta →	-0.110	-2.432	.005	.018	3	1
UCEC	eIF4G →	+0.282	+2.321	.020	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

ERK2 by FBXO28 expression — UCEC

Explore this box plot interactively →