FBXO24

Across TCGA patient cohorts, FBXO24 mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FBXO24-associated genes across cancer lineages are JNK2, ATM, and JNK_pT183_Y185. Each is linked with FBXO24 in more than 1 cancer types. Because this analysis shows association rather than direction, both FBXO24-to-partner and partner-to-FBXO24 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK2 grouped by FBXO24-low versus FBXO24-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBXO24→partner) and Y-score (partner→FBXO24) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK2 →	+0.212	+1.817	.002	.015	3	2
UCEC	ATM →	-0.537	-1.440	<.001	.024	3	2
SKCM	JNK_pT183_Y185 →	-0.093	-1.440	.047	.023	3	2
SKCM	Smad4 →	+0.103	+2.034	.007	.015	3	2
SKCM	beta-Catenin →	-0.414	-1.874	.021	.047	3	2
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.473	+3.169	.007	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

JNK2 by FBXO24 expression — UCEC

Explore this box plot interactively →