FBXO22

Across TCGA pan-cancer cohorts, FBXO22 mass-spec protein differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of FBXO22’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where FBXO22 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types FBXO22 is over-expressed in tumor, although a few such as CCRCC show the opposite, repressed pattern.

HNSC, LUAD, and CCRCC are the cancer types where FBXO22 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FBXO22 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	II,III,IV	+0.147	<.001	8	view →
LUAD	Female	All	+0.199	<.001	5	view →
CCRCC	All	All	−0.064	.034	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

FBXO22–HNSC

Open the HNSC breakdown →