FBXO22

Across TCGA patient cohorts, FBXO22 mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FBXO22-associated genes across cancer lineages are HER3_pY1289, Annexin-1, and TFRC. Each is linked with FBXO22 in more than 1 cancer types. Because this analysis shows association rather than direction, both FBXO22-to-partner and partner-to-FBXO22 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HER3_pY1289 grouped by FBXO22-low versus FBXO22-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBXO22→partner) and Y-score (partner→FBXO22) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	HER3_pY1289 →	+0.127	+3.000	.041	.036	3	2
BLCA	Annexin-1 →	+0.670	+3.000	.015	.036	3	2
UCEC	TFRC →	+0.495	+3.321	.015	.009	3	2
UCEC	4E-BP1 →	+0.340	+3.459	.001	.005	3	2
BLCA	p21 →	+0.651	+3.000	.003	.036	3	1
UCEC	EGFR_pY1068 →	-0.245	-1.874	.011	.049	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

HER3_pY1289 by FBXO22 expression — BLCA

Explore this box plot interactively →