FBXO21

Across TCGA patient cohorts, FBXO21 protein abundance is significantly associated with the RNA expression of many other genes, with 9,622 significant associations in total. GBM shows the largest number of these associations.

The most reproducible FBXO21-associated genes across cancer lineages are C12orf76, CLEC7A, and FOXK2. Each is linked with FBXO21 in more than 3 cancer types. Because this analysis shows association rather than direction, both FBXO21-to-partner and partner-to-FBXO21 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, FBXO21 versus C12orf76 in OV, with a Pearson correlation of 0.36.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBXO21→partner) and Y-score (partner→FBXO21) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	C12orf76 →	+0.364	+0.452	.001	<.001	3	4
GBM	CLEC7A →	-0.902	-0.267	<.001	.001	3	4
LSCC	FOXK2 →	+0.560	+0.204	.001	.001	3	3
LSCC	METAP2 →	+0.625	+0.283	<.001	<.001	3	3
BRCA	SUDS3 →	+0.397	+0.259	.002	.001	2	4
LSCC	SRSF9 →	+0.380	+0.197	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,622 associations by consensus.

FBXO21 vs C12orf76 — OV

Explore this scatter interactively →