FBXO21

Across TCGA patient cohorts, FBXO21 mutation is significantly associated with the RNA expression of many other genes, with 942 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FBXO21-associated genes across cancer lineages are MIR6821, LINC02644, and ZFYVE19. Each is linked with FBXO21 in more than 1 cancer types. Because this analysis shows association rather than direction, both FBXO21-to-partner and partner-to-FBXO21 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR6821 grouped by FBXO21-low versus FBXO21-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBXO21→partner) and Y-score (partner→FBXO21) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MIR6821 →	+0.579	+4.658	<.001	.001	3	2
HNSC	LINC02644 →	+0.091	+4.424	<.001	.008	3	2
UCEC	ZFYVE19 →	+0.301	+2.194	.008	.001	3	2
UCEC	URM1 →	+0.337	+2.407	.001	.002	3	2
UCEC	MRPL57 →	+0.267	+3.828	.003	<.001	3	2
UCEC	MBD3 →	+0.366	+1.673	.004	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 942 associations by consensus.

MIR6821 by FBXO21 expression — BRCA

Explore this box plot interactively →