FBXO21

Across TCGA patient cohorts, FBXO21 mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FBXO21-associated genes across cancer lineages are eIF4E, Fibronectin, and GATA6. Each is linked with FBXO21 in more than 1 cancer types. Because this analysis shows association rather than direction, both FBXO21-to-partner and partner-to-FBXO21 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by FBXO21-low versus FBXO21-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBXO21→partner) and Y-score (partner→FBXO21) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.189	+2.700	.013	.006	3	2
UCEC	Fibronectin →	-0.275	-3.156	.020	.018	3	2
UCEC	GATA6 →	-0.179	-2.685	.001	.005	3	2
UCEC	Lck →	+0.205	+1.925	.004	.005	3	2
UCEC	N-Ras →	-0.137	-1.912	.001	.005	3	2
UCEC	Caspase-7-cleavedD198 →	+0.661	+2.321	.001	.033	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

eIF4E by FBXO21 expression — UCEC

Explore this box plot interactively →