FBXO21

Across TCGA cell cohorts, FBXO21 mutation is significantly associated with the RNA expression of many other genes, with 18 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible FBXO21-associated genes across cancer lineages are OR8D2, GABRA6, and OR51B6. Each is linked with FBXO21 in more than 1 cancer types. Because this analysis shows association rather than direction, both FBXO21-to-partner and partner-to-FBXO21 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR8D2 grouped by FBXO21-low versus FBXO21-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBXO21→partner) and Y-score (partner→FBXO21) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	OR8D2 →	+0.023	+5.807	<.001	.001	3	2
SOFT_TISSUE	GABRA6 →	+0.568	+3.635	<.001	.007	3	1
SOFT_TISSUE	OR51B6 →	+0.125	+4.515	<.001	<.001	3	1
SOFT_TISSUE	MRGPRX4 →	+0.260	+4.392	<.001	.004	3	1
SOFT_TISSUE	FAM9A →	+0.626	+3.882	.003	.004	3	1
SOFT_TISSUE	LCE1C →	+0.087	+3.882	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

OR8D2 by FBXO21 expression — OVARY

Explore this box plot interactively →