FBXO17

Across TCGA patient cohorts, FBXO17 mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FBXO17-associated genes across cancer lineages are Fibronectin, ACVRL1, and MEK1. Each is linked with FBXO17 in more than 1 cancer types. Because this analysis shows association rather than direction, both FBXO17-to-partner and partner-to-FBXO17 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Fibronectin grouped by FBXO17-low versus FBXO17-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBXO17→partner) and Y-score (partner→FBXO17) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Fibronectin →	-0.381	-2.449	.013	.019	3	1
UCEC	ACVRL1 →	-0.194	-3.150	.002	.019	3	1
UCEC	MEK1 →	+0.506	+2.999	.002	.035	3	1
UCEC	Myosin-IIa_pS1943 →	+0.205	+1.887	.033	.031	3	1
UCEC	p62 Lck ligand →	+0.532	+2.179	<.001	.034	3	1
UCEC	PEA-15_pS116 →	+0.450	+2.999	.005	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

Fibronectin by FBXO17 expression — UCEC

Explore this box plot interactively →