FBXO17

Across TCGA cell cohorts, FBXO17 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FBXO17-associated genes across cancer lineages are RSPH6A, ZNF831, and VAX1. Each is linked with FBXO17 in more than 1 cancer types. Because this analysis shows association rather than direction, both FBXO17-to-partner and partner-to-FBXO17 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RSPH6A grouped by FBXO17-low versus FBXO17-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBXO17→partner) and Y-score (partner→FBXO17) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	RSPH6A →	+0.137	+3.466	<.001	.005	3	1
LARGE_INTESTINE	ZNF831 →	+0.011	+3.103	<.001	.004	3	1
LARGE_INTESTINE	VAX1 →	+0.943	+3.519	<.001	.007	3	1
LARGE_INTESTINE	FOXI2 →	+0.013	+3.217	<.001	.006	3	1
LARGE_INTESTINE	OR6Q1 →	+0.012	+3.700	<.001	.009	3	1
CNS	IL17A →	+0.008	+4.772	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

RSPH6A by FBXO17 expression — LARGE_INTESTINE

Explore this box plot interactively →