FBXO11

Across TCGA patient cohorts, FBXO11 mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FBXO11-associated genes across cancer lineages are STAT3_pY705, FOXO3a_pS318_S321, and JNK2. Each is linked with FBXO11 in more than 2 cancer types. Because this analysis shows association rather than direction, both FBXO11-to-partner and partner-to-FBXO11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, STAT3_pY705 grouped by FBXO11-low versus FBXO11-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBXO11→partner) and Y-score (partner→FBXO11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	STAT3_pY705 →	-0.408	-2.321	<.001	.033	3	3
UCEC	FOXO3a_pS318_S321 →	-0.132	-2.312	.022	.034	3	2
UCEC	JNK2 →	+0.262	+2.584	.004	.011	3	2
UCEC	mTOR →	-0.268	-2.584	<.001	.011	3	2
UCEC	Caspase-7-cleavedD198 →	+0.913	+2.584	<.001	.011	3	2
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.701	+2.331	.003	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

STAT3_pY705 by FBXO11 expression — UCEC

Explore this box plot interactively →