FBXO11

Across TCGA cell cohorts, FBXO11 mutation is significantly associated with the mutation status of many other genes, with 3,386 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FBXO11-associated genes across cancer lineages are BRD1, BRWD3, and FLII. Each is linked with FBXO11 in more than 4 cancer types. Because this analysis shows association rather than direction, both FBXO11-to-partner and partner-to-FBXO11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BRD1 grouped by FBXO11-low versus FBXO11-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBXO11→partner) and Y-score (partner→FBXO11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	BRD1 →	+4.459	+5.277	.005	.005	1	5
UPPER_AERODIGESTIVE_TRACT	BRWD3 →	+4.392	+4.954	.008	.008	1	5
UPPER_AERODIGESTIVE_TRACT	FLII →	+4.392	+4.954	.008	.008	1	5
BLOOD_Leukemia	PCNX3 →	+2.465	+3.156	.005	.005	1	5
BLOOD_Lymphoma	FBN2 →	+1.947	+2.584	.003	.003	1	5
BLOOD_Leukemia	SBF1 →	+2.202	+3.442	.002	.002	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,386 associations by consensus.

BRD1 by FBXO11 expression — CNS

Explore this box plot interactively →