FBXL8

Across TCGA pan-cancer cohorts, FBXL8 mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of FBXL8’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where FBXL8 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types FBXL8 is over-expressed in tumor, although a few such as LUAD and LSCC show the opposite, repressed pattern.

LUAD, LSCC, and HNSC are the cancer types where FBXL8 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FBXL8 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Male	III,IV	−0.568	<.001	9	view →
LSCC	Male	All	−0.597	<.001	8	view →
HNSC	Male	III,IV	−0.343	<.001	8	view →
CCRCC	All	All	+0.179	.001	3	view →
PDAC	All	II,III,IV	+0.375	.034	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

FBXL8–LUAD

Open the LUAD breakdown →