Across TCGA patient cohorts, FBXL7 mutation is significantly associated with the RNA expression of many other genes, with 7,720 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FBXL7-associated genes across cancer lineages are CCNB2, NAE1, and MAD2L1. Each is linked with FBXL7 in more than 4 cancer types. Because this analysis shows association rather than direction, both FBXL7-to-partner and partner-to-FBXL7 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBXL7→partner) and Y-score (partner→FBXL7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	CCNB2 →	+0.819	+3.343	.003	.005	3	5
UCEC	NAE1 →	+0.589	+2.632	<.001	<.001	3	5
UCEC	MAD2L1 →	+0.853	+2.343	<.001	<.001	3	5
UCEC	DDIAS →	+0.609	+1.839	<.001	<.001	3	5
UCEC	GLOD4 →	+0.572	+3.010	<.001	<.001	3	5
UCEC	TMEM126B →	+0.341	+1.815	.003	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,720 associations by consensus.

Exploration

FBXL7 survival (RNA) · tumor vs normal (RNA) · all FBXL7 data types