Across TCGA patient cohorts, FBXL7 mutation is significantly associated with the total protein of many other genes, with 77 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FBXL7-associated genes across cancer lineages are Cyclin-B1, ATM, and 4E-BP1. Each is linked with FBXL7 in more than 3 cancer types. Because this analysis shows association rather than direction, both FBXL7-to-partner and partner-to-FBXL7 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBXL7→partner) and Y-score (partner→FBXL7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.638	+2.700	<.001	<.001	3	4
UCEC	ATM →	-0.601	-2.986	<.001	<.001	3	4
UCEC	4E-BP1 →	+0.301	+3.700	<.001	.001	3	4
UCEC	Cyclin-E2 →	+0.112	+1.459	.041	.012	3	4
COAD	JNK_pT183_Y185 →	-0.235	-2.415	.005	.003	3	3
COAD	c-Kit →	-0.659	-1.917	<.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 77 associations by consensus.

Exploration

FBXL7 survival (RNA) · tumor vs normal (RNA) · all FBXL7 data types