Across TCGA cell cohorts, FBXL7 mutation is significantly associated with the RNA expression of many other genes, with 637 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FBXL7-associated genes across cancer lineages are PROSER3, ZFP1, and PSG6. Each is linked with FBXL7 in more than 1 cancer types. Because this analysis shows association rather than direction, both FBXL7-to-partner and partner-to-FBXL7 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBXL7→partner) and Y-score (partner→FBXL7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	PROSER3 →	+0.642	+3.206	.001	.006	3	2
LUNG_NSCLC_LUAD	ZFP1 →	+0.529	+3.206	.009	.006	3	2
LUNG_SCLC	PSG6 →	+0.061	+3.523	<.001	.008	3	2
LARGE_INTESTINE	RAP1GDS1 →	+0.524	+2.628	.002	.002	3	2
LARGE_INTESTINE	NOB1 →	+0.479	+3.192	.008	.007	3	2
LARGE_INTESTINE	KLHL11 →	+0.667	+3.169	.004	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 637 associations by consensus.

Exploration

FBXL7 survival (RNA) · tumor vs normal (RNA) · all FBXL7 data types