Across TCGA patient cohorts, FBXL6 mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FBXL6-associated genes across cancer lineages are ETS-1, PEA-15_pS116, and AMPK_pT172. Each is linked with FBXL6 in more than 1 cancer types. Because this analysis shows association rather than direction, both FBXL6-to-partner and partner-to-FBXL6 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBXL6→partner) and Y-score (partner→FBXL6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ETS-1 →	+0.418	+3.321	.012	.010	3	1
UCEC	PEA-15_pS116 →	+0.503	+3.321	.006	.010	3	1
UCEC	AMPK_pT172 →	+0.489	+2.183	.023	.035	3	1
UCEC	4E-BP1_pT37_T46 →	-0.611	-3.000	.001	.036	3	1
UCEC	FASN →	-0.618	-3.321	.002	.010	2	1
UCEC	NF2 →	+0.386	+3.000	<.001	.036	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

Exploration

FBXL6 survival (RNA) · tumor vs normal (RNA) · all FBXL6 data types