Across TCGA cell cohorts, FBXL6 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FBXL6-associated genes across cancer lineages are SLC15A5, KRTAP9-8, and OR10Z1. Each is linked with FBXL6 in more than 1 cancer types. Because this analysis shows association rather than direction, both FBXL6-to-partner and partner-to-FBXL6 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBXL6→partner) and Y-score (partner→FBXL6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SLC15A5 →	+0.017	+4.415	<.001	.007	3	2
OVARY	KRTAP9-8 →	+0.025	+4.807	<.001	.003	3	1
OVARY	OR10Z1 →	+0.065	+4.807	<.001	.003	3	1
BLOOD_Leukemia	IQCF5 →	+0.121	+5.201	<.001	.006	3	1
LARGE_INTESTINE	FAM205A →	+0.030	+4.614	<.001	.002	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

Exploration

FBXL6 survival (RNA) · tumor vs normal (RNA) · all FBXL6 data types