FBXL5

Across TCGA patient cohorts, FBXL5 RNA expression is significantly associated with the protein abundance of many other proteins, with 15,182 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible FBXL5-associated proteins across cancer lineages are WDR75, NOL11, and PDCD11. Each is linked with FBXL5 in more than 5 cancer types. Because this analysis shows association rather than direction, both FBXL5-to-partner and partner-to-FBXL5 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, FBXL5 versus WDR75 in BRCA, with a Pearson correlation of -0.59.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (FBXL5→partner) and Y-score (partner→FBXL5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	WDR75 →	-0.375	-0.745	<.001	<.001	3	6
BRCA	NOL11 →	-0.357	-0.622	<.001	<.001	3	6
BRCA	PDCD11 →	-0.386	-0.693	<.001	<.001	3	6
LUAD	GNL3 →	-0.329	-0.406	<.001	<.001	3	6
GBM	RPS3 →	-0.228	-0.272	<.001	.006	3	6
GBM	RPS5 →	-0.226	-0.306	.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,182 associations by consensus.

FBXL5 vs WDR75 — BRCA

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