FBXL5

Across TCGA patient cohorts, FBXL5 protein abundance is significantly associated with the RNA expression of many other genes, with 1,930 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible FBXL5-associated genes across cancer lineages are POLE2, GINS1, and CENPI. Each is linked with FBXL5 in more than 1 cancer types. Because this analysis shows association rather than direction, both FBXL5-to-partner and partner-to-FBXL5 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, FBXL5 versus POLE2 in LSCC, with a Pearson correlation of 0.67.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBXL5→partner) and Y-score (partner→FBXL5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	POLE2 →	+1.354	+1.202	<.001	.001	3	2
LSCC	GINS1 →	+1.309	+1.232	<.001	<.001	3	2
COAD	CENPI →	+1.028	+0.861	.009	.001	3	2
LSCC	MCM4 →	+1.056	+0.961	<.001	<.001	3	2
COAD	ASF1B →	+0.956	+0.658	<.001	<.001	3	2
BRCA	UBE2S →	+2.312	+1.495	.005	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,930 associations by consensus.

FBXL5 vs POLE2 — LSCC

Explore this scatter interactively →