FBXL5

Across TCGA patient cohorts, FBXL5 mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FBXL5-associated genes across cancer lineages are JNK_pT183_Y185, ERK2, and MEK1. Each is linked with FBXL5 in more than 2 cancer types. Because this analysis shows association rather than direction, both FBXL5-to-partner and partner-to-FBXL5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK_pT183_Y185 grouped by FBXL5-low versus FBXL5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBXL5→partner) and Y-score (partner→FBXL5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.195	-3.169	<.001	<.001	3	3
UCEC	ERK2 →	+0.184	+1.584	.004	.009	3	2
UCEC	MEK1 →	+0.341	+2.584	.005	.001	3	2
UCEC	ATM →	-0.538	-1.584	<.001	.009	3	2
UCEC	Chk2_pT68 →	-0.183	-3.880	.003	<.001	3	2
UCEC	Di-Ras3 →	-0.124	-3.446	.012	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

JNK_pT183_Y185 by FBXL5 expression — UCEC

Explore this box plot interactively →