FBXL4

Across TCGA pan-cancer cohorts, FBXL4 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated FBXL4 data layer compared with 25 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher FBXL4 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated FBXL4 expression acts as an unfavorable survival marker, although some lineages such as UCEC and LSCC show a favorable association.

PDAC, UCEC, and GBM are the cancer types where FBXL4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Median	All	0.293	0.666	.030	7	view →
UCEC	DFS	Median	All	0.927	0.781	.016	6	view →
GBM	DFS	Quartile	All	0.134	0.573	.002	5	view →
LSCC	OS	Tertile	III,IV	0.979	0.531	.026	4	view →
LUAD	DFS	Median	All	0.903	0.437	.009	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

FBXL4–PDAC (OS)

Open the PDAC breakdown →