FBXL4

Across TCGA patient cohorts, FBXL4 protein abundance is significantly associated with the RNA expression of many other genes, with 2,649 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible FBXL4-associated genes across cancer lineages are SOS2, ZFYVE21, and FOXP1. Each is linked with FBXL4 in more than 1 cancer types. Because this analysis shows association rather than direction, both FBXL4-to-partner and partner-to-FBXL4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, FBXL4 versus SOS2 in BRCA, with a Pearson correlation of -0.24.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBXL4→partner) and Y-score (partner→FBXL4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SOS2 →	-0.537	-0.385	.002	<.001	3	2
BRCA	ZFYVE21 →	-0.463	-0.493	.007	<.001	3	2
BRCA	FOXP1 →	-0.506	-0.382	<.001	<.001	3	2
PDAC	YLPM1 →	-0.710	-0.711	<.001	.001	3	2
LUAD	CRYGN →	-0.667	-0.279	.008	.007	3	2
BRCA	MARCHF7 →	-0.425	-0.363	.002	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,649 associations by consensus.

FBXL4 vs SOS2 — BRCA

Explore this scatter interactively →