FBXL4

Across TCGA patient cohorts, FBXL4 mutation is significantly associated with the RNA expression of many other genes, with 1,066 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FBXL4-associated genes across cancer lineages are OR6C68, LINC01047, and UBE2L2. Each is linked with FBXL4 in more than 2 cancer types. Because this analysis shows association rather than direction, both FBXL4-to-partner and partner-to-FBXL4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR6C68 grouped by FBXL4-low versus FBXL4-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBXL4→partner) and Y-score (partner→FBXL4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	OR6C68 →	+0.105	+6.814	<.001	<.001	3	3
CESC	LINC01047 →	+0.056	+5.306	<.001	.006	3	2
COAD	UBE2L2 →	+0.602	+3.407	<.001	.003	3	2
LIHC	RN7SL435P →	+0.095	+4.544	.007	.009	3	2
CESC	LINC02559 →	+1.376	+6.342	<.001	.001	3	2
CESC	LINC01899 →	+0.046	+5.201	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,066 associations by consensus.

OR6C68 by FBXL4 expression — BLCA

Explore this box plot interactively →