Across TCGA pan-cancer cohorts, FBXL22 Mutation is linked to patient survival in 1 of 34 cancer types, making it a survival-associated FBXL22 data layer compared with 23 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher FBXL22 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated FBXL22 expression acts as an unfavorable survival marker.

ACC are the cancer types where FBXL22 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.195	0.748	.003	3	view →

Pink = unfavorable, green = favorable. Showing the 1 strongest of 1 lineages.

Exploration

Same gene, other analysis: FBXL22 tumor-vs-normal RNA expression · all FBXL22 data types