FBXL20

Across TCGA patient cohorts, FBXL20 mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FBXL20-associated genes across cancer lineages are Lck, p27_pT198, and EGFR_pY1068. Each is linked with FBXL20 in more than 1 cancer types. Because this analysis shows association rather than direction, both FBXL20-to-partner and partner-to-FBXL20 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Lck grouped by FBXL20-low versus FBXL20-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBXL20→partner) and Y-score (partner→FBXL20) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Lck →	+0.218	+1.906	.006	.016	3	2
UCEC	p27_pT198 →	+0.123	+3.321	.004	.010	3	2
UCEC	EGFR_pY1068 →	-0.288	-1.906	.004	.016	3	1
UCEC	eIF4E →	+0.235	+3.700	.005	.001	3	1
UCEC	A-Raf_pS299 →	-0.185	-3.459	<.001	.005	3	1
UCEC	ERK2 →	+0.208	+2.459	.007	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

Lck by FBXL20 expression — UCEC

Explore this box plot interactively →