FBXL2

Across TCGA patient cohorts, FBXL2 mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FBXL2-associated genes across cancer lineages are INPP4B, ATM, and Caspase-7-cleavedD198. Each is linked with FBXL2 in more than 1 cancer types. Because this analysis shows association rather than direction, both FBXL2-to-partner and partner-to-FBXL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, INPP4B grouped by FBXL2-low versus FBXL2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FBXL2→partner) and Y-score (partner→FBXL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	INPP4B →	-0.295	-2.906	.008	.001	3	2
UCEC	ATM →	-0.687	-3.794	<.001	<.001	3	2
UCEC	Caspase-7-cleavedD198 →	+0.534	+1.505	.009	.034	3	2
UCEC	Cyclin-E2 →	+0.139	+1.440	.017	.024	3	2
UCEC	EGFR_pY1068 →	-0.249	-2.584	.004	.010	3	1
UCEC	eIF4E →	+0.196	+2.598	.007	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

INPP4B by FBXL2 expression — UCEC

Explore this box plot interactively →